NAC molecular structure and glutathione pathway visualization

NAC (N-Acetylcysteine): Glutathione Restoration and Clinical Evidence

Evidence analysis of N-acetylcysteine (NAC): reliable glutathione precursor with proven antioxidant effects. Early signals in Parkinson's and cognition, but NO strong evidence for protein clump clearance, Alzheimer's treatment, or Long COVID recovery in humans. Ferroptosis inhibition relevant to spike-induced microglial death, disulfide bond disruption for spike aggregates, and MMP-9/BBB protection mechanisms.

Lion's Mane mushroom showing white cascading spine-like structures

Lion's Mane Mushroom: NGF/BDNF Support and Cognitive Evidence

Evidence analysis of Lion's Mane (Hericium erinaceus): erinacines and hericenones stimulate NGF/BDNF production. Modest cognitive benefits in older adults with MCI (MMSE +0.8-1.5 points); inconsistent results in healthy young adults. NGF/BDNF support for spike-induced neurodegeneration, basal ganglia recovery, and hippocampal neuroprotection relevant to HAND criteria and Long COVID cognitive impairment.