Evidence analysis of Centella asiatica (Gotu Kola): triterpenoids (asiatic acid, asiaticoside) for neuroprotection, wound healing, anxiety. In vitro/animal data strong; human cognitive evidence weak/inconsistent. Topical wound healing has moderate evidence.
Evidence analysis of Lion's Mane (Hericium erinaceus): erinacines and hericenones stimulate NGF/BDNF production. Modest cognitive benefits in older adults with MCI (MMSE +0.8-1.5 points); inconsistent results in healthy young adults. NGF/BDNF support for spike-induced neurodegeneration, basal ganglia recovery, and hippocampal neuroprotection relevant to HAND criteria and Long COVID cognitive impairment.