Independent · Mechanism-First · Evidence-Graded
Health evidence reviews, original sequence research, mechanisms and documentary investigations: the clearance-and-tolerance framework, pathway mechanics, and the natural compounds that act as levers within it.
Start here · All articles · Methodology · About the publication
Investigations into natural compounds, cellular health mechanisms, and evidence-based wellness protocols.
The most developed work on this site. A unified framework for chronic spike-related illness as systemic clearance and tolerance failure under persistent antigenic drive: pathway mechanics (mTOR, glymphatic, SIRT1), five mechanistic subtypes, a tiered biomarker matrix, and intervention protocols. Evidence-graded, primary-source, falsifiable.
Evidence analysis of Lion's Mane (Hericium erinaceus): erinacines and hericenones stimulate NGF/BDNF production. Modest cognitive benefits in older adults with MCI (MMSE +0.8-1.5 points); inconsistent results in healthy young adults. NGF/BDNF support for spike-induced neurodegeneration, basal ganglia recovery, and hippocampal neuroprotection relevant to HAND criteria and Long COVID cognitive impairment.