Spikeopathy Pathways: mTOR, Glymphatic Clearance, and the SIRT1/PGC-1α Axis
The clearance-system failure hypothesis of spikeopathy. Two systems break together: mTOR-driven autophagy inside cells, and glymphatic flow between them. SIRT1/PGC-1α is the connecting axis. With 2025 DTI-ALPS imaging, the dual-mTOR model, and the levers that actually touch the cycle.